The AB Blood Group System Phenotype Does Not Play a Role inInfection in Cats.

Abstract

Previous studies have evaluated the association between different blood groups and human infection with. No similar studies exist in cats. The objective of this study was to evaluate the role of some risk or protective factors, including the AB blood type system phenotypes, ininfection in cats. Feline sera and surplus EDTA anticoagulated blood samples, for which AB blood group system phenotypes had been determined, were analyzed forantibodies (ELISA, cut-off S/P% &#x2265; 50% and IFAT, cut-off &#x2265; 1:64) and DNA (nested and real-time PCR).status and the characteristics of signalment (gender, breed, and age), lifestyle (stray, shelter, privately-owned), origin (Northern or Southern Italy), and retroviral infection serostatus of the population were evaluated using the Chi-square test, with calculation of the Odds Ratio (OR) in cases of statistically significant association (< 0.05). A total of 199 samples were analyzed, of which 178 were phenotype A, 15 were phenotype B, and 6 were phenotype AB. Of these, 57/199 (28.6%) were positive for: 5 were positive at PCR, 33 at ELISA, and 19 at IFAT. Of the 57 positive cats, 52/57 were phenotype A, 3/57 phenotype B, and 2/57 phenotype AB, with no significant association withinfection. FIV seropositive cats had a higher risk (OR = 3.1,= 0.0043) of testingpositive. This study did not find an association betweeninfection and the feline blood types investigated; therefore, based on our results, AB blood group system phenotypes do not seem to play a role ininfection in cats. These findings contribute to our knowledge of the role of blood types in disease susceptibility in cats.