Peer-reviewed veterinary case report
Dog breeds and size linked to osteosarcoma risk in Poland
By Sapierzyński, R & Czopowicz, M·Published in Polish journal of veterinary sciences·2017·.·View original on PubMed →
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Original publication title: The animal-dependent risk factors in canine osteosarcomas.
- Species:
- dog
Plain-English summary
A study found that certain dog breeds, especially large and giant breeds like Rottweilers, are more likely to develop osteosarcoma, a type of bone cancer. The research showed that nearly half of the dogs diagnosed with this cancer were large breeds, and most tumors occurred in the limbs rather than the spine. Interestingly, there was no difference in risk between male and female dogs, and mixed-breed dogs were less commonly affected. This suggests that genetics play a significant role in the development of osteosarcoma in dogs, particularly in predisposed breeds like Rottweilers.
People also search for: Rottweiler osteosarcoma risk · dog bone cancer symptoms · large breed cancer predisposition
Abstract
Canine osteosarcoma (OSA) is a malignant neoplastic tumor, which develops from the primitive mesenchymal stem cell, that has or can acquire the capacity to produce neoplastic osteoid with possible neoplastic bone formation. Predisposition of some dog breeds to OSA indicates genetic background of oncogenesis. The aim of the study was to characterize animal-dependent risk factors for canine osteosarcoma development in Poland. The study was conducted on canine patients diagnosed cytologically or histopathologically as having OSA, and data on age, breed, sex, as well as tumor location and character were recorded. No sex predisposition to OSA was observed, mongrels were significantly underrepresented. Large and giant dogs accounted for 47% and 35% of all pedigree dogs, respectively, and both proved predisposed to OSA. A vast majority of OSA developed in the skeleton (appendicular skeleton was more commonly affected than axial skeleton), soft tissues were affected less often. Rottweiler dogs are strongly predisposed to OSA, suggesting that the genetic background is involved in the tumor development, and indicates that dogs of this breed are a promising object for further studies on OSA pathogenesis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28865206/