Peer-reviewed veterinary case report
Vitamin D receptor gene linked to calcium oxalate bladder stones
By Chamsuwan, Sumonwan et al.·Published in Journal of veterinary internal medicine·2021·Department of Physiology·View original on PubMed →
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Original publication title: The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs.
- Species:
- dog
Plain-English summary
A group of 35 dogs with calcium oxalate (CaOx) bladder stones were studied to see if certain genetic factors related to vitamin D could increase their risk of developing these stones. The research found that dogs with specific gene variations had a higher chance of forming CaOx stones compared to those without these variations. Interestingly, the dogs with a certain genetic makeup had lower levels of calcium in their urine, which might suggest a link between vitamin D metabolism and stone formation. Understanding these genetic factors could help veterinarians better manage and prevent bladder stones in dogs.
People also search for: dog bladder stones treatment · calcium oxalate stones in dogs · vitamin D and dog health
Abstract
BACKGROUND: Polymorphisms of the vitamin D receptor (VDR) are associated with calcium oxalate (CaOx) nephrolithiasis in humans. OBJECTIVES: To investigate the association between VDR polymorphisms and susceptibility to CaOx urolithiasis in dogs. ANIMALS: Thirty-five dogs with CaOx urolithiasis were compared with 40 stone-free dogs. METHODS: This was a case-control study. Two VDR gene polymorphisms (rs851998024 and rs852900542) were detected by specific TaqMan real-time polymerase chain reaction assay, and their relationship with serum 1,25-dihydroxyvitamin D, serum and urinary electrolyte concentrations was evaluated. RESULTS: The distribution of the rs852900542 polymorphism was significantly different between the case and the control dogs (x = 6.369, P = .04). Dogs with a CC or CT genotype had an increased risk of CaOx stones than those with the TT genotype (odds ratio = 3.82, 95% confidence interval 1.04-13.98). The CaOx dogs with the TT genotype had a significantly lower urinary calcium-to-creatinine ratio than the CT+CC genotypes. 1,25-(OH)2D concentrations did not differ between the cases and the controls (308.7 ± 217.4 vs 286.7 ± 185.1 pg/mL, P = .45). CONCLUSIONS AND CLINICAL IMPORTANCE: This finding suggests that vitamin D metabolism might play a role in CaOx stone formation in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34322901/