Peer-reviewed veterinary case report
Lipid peroxide levels in dog spinal fluid linked to brain disease
By Kitagawa, M et al.·Published in Veterinary research communications·2006·Department of Preventive Veterinary Medicine and Animal Health, Japan·View original on PubMed →
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Original publication title: The clinical significance of cerebrospinal fluid lipid peroxides in central nervous system disease.
- Species:
- dog
Plain-English summary
A group of 44 dogs with neurological symptoms like seizures or weakness in their back legs were examined at a veterinary hospital. Some dogs had abnormal MRI results, while others had normal scans. The researchers measured levels of certain substances in the dogs' cerebrospinal fluid and blood, finding that higher levels of lipid peroxides were linked to the dogs with abnormal MRI results. This suggests that testing these levels could help identify issues in the brain or spinal cord, such as swelling or tumors.
People also search for: dog seizure causes · dog weakness back legs · dog MRI results explained
Abstract
Forty-four dogs were referred to our hospital presenting with neurological symptoms such as seizure or paraparesis. Magnetic resonance imaging (MRI) revealed abnormal results in 21 (abnormal MRI group) and normal results in 23 dogs (normal MRI group). Cerebrospinal fluid (CSF) (normal MRI group, n = 22; abnormal MRI group, n = 21) and serum lipid peroxide (LP) concentrations (normal MRI group, n = 11; abnormal MRI group, n = 15) were measured in a number of these dogs, and revealed a significant difference in the CSF/serum LP values (normal MRI group, n = 10; abnormal MRI group, n = 14) between the abnormal and the normal MRI groups (t-test and Mann-Whitney U-test p < 0.05). No other significant differences were observed. CSF/serum LP values exceeding 1.0 were exhibited in 10 of 14 dogs (71%) in the abnormal MRI group, and in 1 of 10 dogs (10%) in the normal MRI group. In the remaining animals, 4 dogs of the abnormal MRI group showed CSF/serum values lower than 1.0, 3 dogs had morphological abnormalities but no abnormal MRI signals in the central nervous system, and 1 dog had an abnormal MRI signal but no pathological abnormality. In the CSF analysis, 3 of 16 dogs (19%) of the abnormal MRI groupshowed abnormal cell counts and/or protein content. We conclude that the CSF/serum LP value can be used for the detection of neurological lesions such as oedema, inflammation and tumour.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16400600/