Peer-reviewed veterinary case report
How dog kidney disease changes urine purine levels
By Rivara, C M et al.·Published in The Veterinary record·2013·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: The effect of disease on the urinary purine metabolite concentrations in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with chronic kidney disease, cancer, or hyperadrenocorticism (Cushing's disease) had higher levels of certain substances in their urine compared to healthy dogs. Specifically, the levels of xanthine and uric acid were significantly increased, which could help veterinarians identify these diseases. The study suggests that measuring these urinary metabolites could be useful in diagnosing and monitoring these conditions in dogs. Understanding these changes can help guide treatment decisions and improve care for affected pets.
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Abstract
This prospective study was designed to determine the urinary concentrations of purine metabolites in healthy and diseased dogs. The goals were to test the hypothesis that urine concentrations of terminal purine metabolites will identify dogs with diseases that disturb purine degradation. Five hundred and sixty-three client-owned dogs admitted sequentially to the veterinary medical centre were included. Dogs were divided into groups on the basis of their disease. Urine concentrations of xanthine, uric acid, allantoin and creatinine were measured by high-pressure liquid chromatography. Xanthine and uric acid to creatinine ratios were significantly increased in dogs with chronic kidney disease (p = 0.01). The uric acid to creatinine ratio was significantly increased in dogs with cancer compared with clinically healthy dogs (p = 0.04), and significantly increased in dogs receiving chemotherapy for their disease (p < 0.01). Compared to clinically healthy dogs, xanthine and uric acid to creatinine ratios were significantly increased in dogs with hyperadrenocorticism (p < 0.01, and 0.04, respectively). Therefore, the results of this study found that the urinary concentrations of purine metabolites in dogs are significantly impacted by systemic disease. Cancer, chronic kidney disease, and hyperadrenocorticism are associated with altered concentrations of urinary purine metabolites in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23913176/