Peer-reviewed veterinary case report
Best medicines to stop vomiting in cats after dexmedetomidine
By Gölgeli Bedir, Ayşe et al.·Published in Veterinary medicine and science·2025·Department of Surgery·View original on PubMed →
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Original publication title: The Effect of Maropitant, Ondansetron and Metoclopramide on Dexmedetomidine-Induced Vomiting in Cats.
- Species:
- cat
Plain-English summary
A group of cats experienced vomiting after receiving a sedative called dexmedetomidine. To help prevent this, they were given different anti-nausea medications: maropitant, ondansetron, or metoclopramide, before the sedative was administered. The results showed that all three medications significantly reduced the vomiting and retching compared to a control group that received saline. However, there was no major difference in effectiveness between the three medications. This means that any of these options could be used to help manage vomiting in cats after sedation.
People also search for: cat vomiting after sedation · maropitant for cats · ondansetron for cat nausea · metoclopramide for cat vomiting
Abstract
OBJECTIVES: Vomiting is frequently observed in cats after dexmedetomidine administration. This study aimed to compare the efficacy of different antiemetics in preventing vomiting in cats after dexmedetomidine administration. METHODS: Sixty-four cats were randomly allocated to receive saline solution (0.9% NaCl, 0.1 mL/kg, SC), maropitant (1 mg/kg, SC), ondansetron (0.22 mg/kg, IM) or metoclopramide (1 mg/kg, IM) 30 min before the intramuscular administration of dexmedetomidine (25 µg/kg). Duration of vomiting, severity of vomiting and nausea signs (sialorrhoea, lip licking, retching and vomiting) was recorded for 30 min after dexmedetomidine administration. RESULTS: The duration and severity of vomiting were significantly reduced in groups that received maropitant, ondansetron or metoclopramide compared to the saline group. Although differences were observed in retching and vomiting between the saline and other groups (p < 0.001), there were no significant differences in sialorrhoea or lip licking (p = 0.34 and p = 0.12, respectively). CONCLUSIONS: Maropitant, ondansetron and metoclopramide were found to significantly reduce retching and vomiting compared to the control group. In conclusion, no significant difference was found among maropitant, ondansetron and metoclopramide groups in the prevention of dexmedetomidine-induced vomiting in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39792081/