The effect of the treatment and prevention complex on the activity of the antioxidant protection system in experimental periodontitis combined with stress.

Abstract

OBJECTIVE: Aim: To investigate the periodontal protective properties of the developed therapeutic and prophylactic complex in terms of pro- and antiradical protection system on an experimental toxic calcium-deficiency model of periodontitis under noise and cold stress. PATIENTS AND METHODS: Materials and Methods: Calcium-deficiency toxicity was modelled in animals with the addition of noise and cold stress. The effect of the developed therapeutic and prophylactic complex consisting of the oral gel and the food supplement on the indicators of pro- and antioxidant protection in the blood and periodontal tissues of rats was studied. RESULTS: Results: The results of our biochemical study indicate significant disturbances in the blood and periodontium of experimental animals with modelled periodontitis with the addition of noise and cold stress, the balance of pro- and various links of the antioxidant system. Thus, in animals with experimental periodontitis, an increase in radical oxidant system and an imbalance in the antioxidant system were detected - a multidirectional change in the activity of catalase and superoxide dismutase, a decrease in the activity of both in the blood and in periodontal tissues, compared to intact animals. This resulted in an increase in the malondialdehyde/glutathione peroxidase ratio, indicating a state of depletion of this protection system and the development of oxidative stress. CONCLUSION: Conclusions: The treatment and prophylactic complex developed by us provides a high level of antiradical protection, both at the local (in periodontal tissues) and systemic levels, which indicates its pathogenetic orientation.