Peer-reviewed veterinary case report
Prednisone speeds blood clotting recovery in dogs with leishmaniasis
By Cortese, Laura et al.·Published in Veterinary journal (London, England : 1997)·2008·Department of Veterinary Clinical Sciences, Italy·View original on PubMed →
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Original publication title: The effects of prednisone on haemostasis in leishmaniotic dogs treated with meglumine antimoniate and allopurinol.
- Species:
- dog
Plain-English summary
Thirty dogs with leishmaniasis (a disease caused by a parasite) were treated to see how different medications affected their blood clotting. Half of the dogs received a combination of two medications, while the other half got the same treatment plus prednisone, a steroid. After 15 days, the dogs on prednisone showed improvement in their blood clotting ability, while the other group took longer to see benefits. Overall, prednisone appeared to help with blood clotting issues in dogs with this condition, but there are both benefits and risks to consider when using steroids.
People also search for: dog leishmaniasis treatment · prednisone for dogs blood clotting · dog blood clotting issues treatment
Abstract
Thirty dogs naturally infected with Leishmania infantum were studied in order to determine the effects of treatment on haemostatic function. The animals were divided randomly into two treatment groups: Group 1 received meglumine antimoniate and allopurinol; Group 2 dogs were given the same treatment plus prednisone. Ten healthy animals were used as untreated controls. Clinical examination and determination of platelet aggregation, coagulation factors and biochemical parameters were undertaken before treatment and after 15, 30 and 60 days. A significant improvement in platelet aggregation was detected after 60 days in Group 1, but only after 15 days in Group 2. In both treated groups, platelet aggregation was lower than in the control group at the end of the study. The results suggest that prednisone may be a useful tool in the treatment of haemostatic disorders during canine leishmaniosis. The potential benefits and risks due to the use of corticosteroids in the treatment of leishmaniosis are discussed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17629526/