Peer-reviewed veterinary case report
Allopurinol helps prevent blood flow changes after kidney artery
By Peto, K et al.·Published in Clinical hemorheology and microcirculation·2007·Department of Operative Techniques and Surgical Research·View original on PubMed →
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Original publication title: The effects of renal ischemia-reperfusion on hemorheological factors: preventive role of allopurinol.
- Species:
- dog
Plain-English summary
A group of dogs underwent surgery where one kidney's blood supply was temporarily cut off for 45 minutes, then restored. After the surgery, blood tests showed that the dogs experienced changes in how their blood flowed and how their red blood cells behaved. However, dogs that received a medication called allopurinol before the surgery had better blood flow and red blood cell function afterward. This suggests that giving allopurinol before kidney surgery can help prevent some of the negative effects on blood flow that can happen after the procedure.
People also search for: dog kidney surgery recovery · allopurinol for dogs · dog blood flow problems after surgery
Abstract
Changes in hemorheological parameters were studied in dogs following unilateral renal artery clamping (45-minute ischemia then reperfusion), with and without preoperative administration of allopurinol. Sham-operated animals were also evaluated. Blood samples were collected preoperatively, at beginning and at 30, 60 and 120 minutes of reperfusion, then on the 1st, 3rd, 5th and 7th days. Filtration properties of erythrocytes (relative cell transit time, RCTT), whole blood and plasma viscosity (WBV, PV), fibrinogen level and hematology parameter were determined. RCTT significantly increased for both ischemic groups at 30 minutes of reperfusion, and remained elevated on the 1st and 2nd postoperative days; these changes were abolished by allopurinol pretreatment. WBV and hematocrit increased on the 1st day, and PV and fibrinogen level showed elevation on 1st-5th postoperative days. We thus conclude that decreases of RBC deformability (i.e., higher RCTT) were characteristic and specific on early postoperative days after renal ischemia-reperfusion and that these alterations were prevented by pre-ischemia administration of allopurinol.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17942987/