Peer-reviewed veterinary case report
Sulforaphane reduces bone cancer cell invasion in dogs
By Rizzo, V L et al.·Published in Veterinary and comparative oncology·2017·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: The effects of sulforaphane on canine osteosarcoma proliferation and invasion.
- Species:
- dog
Plain-English summary
A study looked at how sulforaphane, a compound found in raw vegetables, affects dogs with osteosarcoma, a type of bone cancer. Researchers tested sulforaphane alone and with doxorubicin, a common chemotherapy drug, on cancer cells from dogs. While sulforaphane didn’t kill the cancer cells, it did reduce their ability to invade other tissues and seemed to protect some cells from the harmful effects of doxorubicin. This suggests that sulforaphane might be a helpful supplement for dogs undergoing treatment for osteosarcoma, but more research is needed to confirm its benefits.
People also search for: dog osteosarcoma treatment · sulforaphane for dogs · doxorubicin side effects in dogs
Abstract
Recent evidence in in vitro and in vivo models suggests that sulforaphane (SFN), found in raw cruciferous vegetables, may have utility in chemoprevention, as an antineoplastic agent and as a free radical scavenger. The effects of SFN alone or with doxorubicin on cell viability were examined, as well as cell cycle kinetics, invasion capabilities and apoptosis in three canine osteosarcoma cell line (D17, OS 2.4 and HMPOS). Results showed that SFN could not induce cell death at potentially physiological concentrations (<50 μM), but significantly diminished cell invasion and downregulation of focal adhesion kinase (FAK) signaling. Modest cell cycle changes were observed in each cell line. When doxorubicin was used in conjunction with SFN, there was a protective effect to doxorubicin-induced cytotoxicity in D17 and OS 2.4 cells. Further studies examining SFN as a supplement are warranted, particularly in light of pro-proliferative and cytoprotective properties in canine osteosarcoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27045198/