Peer-reviewed veterinary case report
Advantix prevents Ehrlichia canis infection from ticks in dogs
By Fourie, Josephus Johannes et al.·Published in Parasite (Paris, France)·2013·ClinVet International (Pty) Ltd·View original on PubMed →
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Original publication title: The efficacy of Advantix® to prevent transmission of Ehrlichia canis to dogs by Rhipicephalus sanguineus ticks.
- Species:
- dog
Plain-English summary
Six dogs were tested to see if a topical treatment called Advantix (which contains imidacloprid and permethrin) could prevent a tick-borne infection called Ehrlichia canis. The dogs were exposed to infected ticks, and while four of the untreated dogs became infected and showed symptoms like fever and low platelet counts, the dogs treated with Advantix remained healthy and free of the infection. The treatment was effective for up to four weeks, showing a high success rate in keeping the dogs safe from this disease.
People also search for: dog tick prevention · Ehrlichia canis symptoms in dogs · Advantix for dogs · doxycycline for dog infections
Abstract
The capacity of a topical combination of imidacloprid and permethrin (Advantix(®)) to prevent transmission of Ehrlichia canis was studied in two groups of six dogs. One group served as controls, whereas the other group was treated. All dogs were exposed to E. canis-infected Rhipicephalus sanguineus ticks on Days 7, 14, 21 and Day 28 post acaricidal treatment. The adult R. sanguineus ticks were released into the individual kennels of the dogs to simulate natural tick exposure. In situ tick counts were conducted on Day 9, 16 and 23 and any remaining ticks were counted and removed on Day 30. The efficacy of the acaricidal treatment against R. sanguineus ranged between 96.1% and 98.9% at 48 h post-application and lasted up to 4 weeks. Four out of six control dogs became infected with E. canis, as demonstrated by the presence of specific E. canis antibodies and the detection by PCR of E. canis DNA in blood samples. These dogs became thrombocytopenic and displayed fever and were consecutively rescue-treated by doxycycline. None of the six treated dogs became infected with E. canis, as confirmed by the lack of specific antibodies and absence of E. canis DNA in blood samples. Advantix(®) prevented transmission of E. canis and provided protection against monocytic ehrlichiosis for 4 weeks post acaricidal treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24135158/