Peer-reviewed veterinary case report
Genetic study of epilepsy in Petit Basset Griffon Vendeen dogs
By Deschain, T et al.·Published in Animal genetics·2021·Department of Veterinary and Animal Sciences·View original on PubMed →
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Original publication title: The first genome-wide association study concerning idiopathic epilepsy in Petit Basset Griffon Vendeen.
- Species:
- dog
Plain-English summary
A study focused on Petit Basset Griffon Vendeens found that this breed has a higher chance of developing idiopathic epilepsy, which is a type of seizure disorder with no known cause. Researchers looked at the DNA of 23 affected dogs and 30 healthy ones to find genetic markers that might be linked to the disease. They identified some potential areas in the genome that could be related to epilepsy but did not find specific genetic changes that would explain why these dogs develop seizures. More research is needed to fully understand the genetic factors involved in this condition.
People also search for: Petit Basset Griffon Vendeen epilepsy · dog seizures causes · genetic testing for dog epilepsy
Abstract
The dog breed Petit Basset Griffon Vendeen has a relatively high prevalence of idiopathic epilepsy compared to other dog breeds and previous studies have suggested a genetic cause of the disease in this breed. Based on these observations, a genome-wide association study was performed to identify possible epilepsy-causing loci. The study included 30 unaffected and 23 affected dogs, genotyping of 170K SNPs, and data analysis using plink and emmax. Suggestive associations at CFA13, CFA24 and CFA35 were identified with markers close to three strong candidate genes. However, subsequent sequencing of exons of the three genes did not reveal sequence variations, which could explain development of the disease. This is, to our knowledge, the first report on loci and genes with a possible connection to idiopathic epilepsy in Petit Basset Griffon Vendeen. However, further studies are needed to conclusively identify the genetic cause of idiopathic epilepsy in this dog breed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34383319/