Peer-reviewed veterinary case report
Protein in urine, kidney changes, and blood pressure in cats
By Williams, Kimberly et al.·Published in Journal of feline medicine and surgery·2024·Western College of Veterinary Medicine, Canada·View original on PubMed →
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Original publication title: The incidence and trends of proteinuria, azotemia and hypertension in cats receiving toceranib phosphate.
- Species:
- cat
Plain-English summary
A group of 32 cats with cancer, including oral squamous cell carcinoma and mast cell tumors, were treated with a medication called toceranib. During the treatment, none of the cats developed worsening kidney issues or high blood pressure, and some even showed a decrease in protein levels in their urine, which is a good sign for kidney health. The cats were monitored for about two months, and those with initial protein in their urine saw improvements alongside reductions in tumor size. This suggests that toceranib can be a safe option for cats with existing kidney concerns when monitored closely.
People also search for: cat cancer treatment toceranib · protein in cat urine · cat kidney health during cancer treatment
Abstract
OBJECTIVES: This retrospective study aimed to determine the incidence and trends of proteinuria, elevations in serum creatinine and urea, and systolic blood pressure in cats undergoing treatment with toceranib. METHODS: In total, 32 cats treated with toceranib for malignancies were analyzed. Cats were included if urinalysis and urine protein:creatinine ratio (UPC) measurements were available at 28 days (T1) and 56 days (T2) after starting the treatment. Cats with concurrent lower urinary tract disease, including urinary tract malignancy, were excluded. Friedman's ANOVA compared variables between time points, and the Spearman test assessed the correlation between treatment duration and UPC. RESULTS: The median starting dose of toceranib was 2.68 mg/kg (range 1.7-3.9). In total, 15 (46.9%) cats received concurrent non-steroidal anti-inflammatory drugs. The most commonly treated tumors were oral squamous cell carcinoma (n = 10) and mast cell tumor (n = 5). None of the 32 cats developed progressive proteinuria or azotemia during the follow-up period (median 56 days; range 56-336). Notably, UPC and serum creatinine were significantly lower at T2 compared with baseline ( = 0.012 and 0.001, respectively). Among the four cats with baseline proteinuria, UPC decreased over time with or without concurrent telmisartan treatment (n = 2). All four of these cats experienced a reduction in tumor size with toceranib concurrently with their decreased UPC. There was no significant correlation between UPC and the duration of toceranib treatment ( = 0.089). Blood pressure was not significantly different over the assessed time points. CONCLUSIONS AND RELEVANCE: The incidence of proteinuria, renal azotemia and hypertension in cats treated with toceranib for neoplasia appears to be low. Toceranib may be a viable treatment option even in cats with pre-existing proteinuria or renal disease, with careful monitoring of trends recommended.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39287178/