Peer-reviewed veterinary case report
Metabolic tumor volume predicts survival in dogs with bone cancer
By Griffin, Lynn R et al.·Published in Veterinary and comparative oncology·2022·Environmental Health and Radiological Sciences Department, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: The prognostic significance of metabolic tumour volume and total lesion glycolysis for dogs staged for appendicular osteosarcoma with fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with appendicular osteosarcoma (a type of bone cancer) underwent a special imaging test called F-FDG PET/CT to assess their tumors. Researchers measured metabolic tumor volume and total lesion glycolysis, which help predict how long dogs might survive after diagnosis. They found that certain measurements were strongly linked to survival rates, with specific values indicating better or worse outcomes. This study suggests that these imaging results can help veterinarians better understand a dog's prognosis and tailor treatment plans accordingly.
People also search for: dog osteosarcoma prognosis · appendicular osteosarcoma treatment · F-FDG PET scan for dogs
Abstract
Metabolic tumour volumes (MTV) and total lesion glycolysis (TLG) are metabolic parameters that are becoming more commonly reported in human medicine to quantify tumours detected on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT). In this retrospective study dogs afflicted with appendicular osteosarcoma that were staged withF-FDG PET/CT had MTV and TLG at a variety of set and fixed thresholds calculated by two observers. These values, along with SUV, were evaluated for prognostic significance in this population of dogs. There was excellent correlation between two observers for all values. Multiple volumetric parameters were significantly associated with survival. SUVhad the highest sensitivity for survival and TLG at 2.5 SUV*cmhad the highest specificity for prediction of survival based on ROC calculations. The SUV, MTV at 2.5 SUV and TLG at 2.5 SUV*cmwere significantly different between dogs that survived more than or less than 1 year. This study is the first of its kind in veterinary medicine that retrospectively evaluated volumetric tumour values for prognostic significance and may provide a basis for standardized method of reportingF-FDG PET/CT results.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33988286/