Peer-reviewed veterinary case report
Kidney problems in dogs caused by NSAID pain medicines
By Lomas, Amy L & Grauer, Gregory F·Published in Journal of the American Animal Hospital Association·2015·From the Department of Clinical Sciences·View original on PubMed →
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Original publication title: The renal effects of NSAIDs in dogs.
- Species:
- dog
Plain-English summary
A study found that nonsteroidal anti-inflammatory drugs (NSAIDs), commonly used to relieve pain in dogs with osteoarthritis, can lead to kidney problems, especially in dogs with chronic kidney disease. While these medications can improve quality of life, they also carry a risk of adverse effects, including renal reactions. This is particularly concerning because dogs have a different response to these drugs compared to humans, with higher levels of certain enzymes that can affect kidney function. Pet owners should discuss the potential risks and benefits of NSAIDs with their veterinarian, especially if their dog has existing kidney issues.
People also search for: dog kidney problems NSAIDs · osteoarthritis pain relief for dogs · NSAIDs side effects in dogs
Abstract
The quality of life for dogs with osteoarthritis can often be improved with nonsteroidal anti-inflammatory drugs (NSAIDs); however, the number of adverse drug events associated with NSAID use reported to the Federal Drug Administration Center for Veterinary Medicine is higher than that for any other companion animal drug. Of those events, adverse renal reactions are the second most reported. NSAIDs produce pharmacologic effects via inhibition of cyclooxygenase (COX), which decreases production of prostanoids. Prostaglandins are synthesized by both the COX-1 and COX-2 enzymes in the healthy kidney and influence renal blood flow, glomerular filtration rate, renin release, and Na excretion. There are important species differences in the renal expression of COX-1 and COX-2. For example, dogs have higher basal levels of COX-2 expression in the kidney compared with humans. In addition, in dogs with chronic kidney disease, an increase in COX-2 expression occurs and synthesis of prostaglandins shifts to the COX-2 pathway. For those reasons, NSAIDs that target COX-2 may be expected to adversely affect renal function in dogs, especially dogs with chronic kidney disease. The purpose of this review was to evaluate the literature to report the renal effects of NSAIDs in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25955147/