Peer-reviewed veterinary case report
Why rituximab likely won't treat canine lymphoma effectively
By Impellizeri, Joseph A et al.·Published in Veterinary journal (London, England : 1997)·2006·Sacramento Animal Medical Group, United States·View original on PubMed →
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Original publication title: The role of rituximab in the treatment of canine lymphoma: an ex vivo evaluation.
- Species:
- dog
Plain-English summary
A study looked at whether rituximab, a medication used in humans for certain types of lymphoma, could help dogs with lymphoma, a type of cancer affecting the immune system. Researchers tested how well rituximab could attach to and reduce B cells in dogs, which are often involved in this cancer. Unfortunately, the results showed that rituximab did not effectively bind to or deplete these cells in dogs, suggesting it may not be a useful treatment option for canine lymphoma.
People also search for: dog lymphoma treatment · rituximab for dogs · canine cancer options
Abstract
Targeting the CD20 receptor that is common to many B-cell Non-Hodgkin's Lymphoma subtypes in people, rituximab is a chimeric monoclonal antibody which has significantly improved disease-free survival rates compared with the use of cytotoxic agents alone. This study evaluated ex vivo canine B cell binding and depletion by rituximab with flow cytometric technique as possible proof of concept for treatment of canine lymphoma. Despite immunohistochemistry supporting CD20 expression, rituximab did not bind or deplete canine B cells and it is unlikely that it will be added to the armamentarium of treatment options for canine lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16624725/