Peer-reviewed veterinary case report
How fast selamectin plus sarolaner kills ticks on cats
By Vatta, Adriano F et al.·Published in Veterinary parasitology·2019·Zoetis, United States·View original on PubMed →
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Original publication title: The speed of kill of a topical combination of selamectin plus sarolaner against induced infestations of Ixodes scapularis ticks on cats.
- Species:
- cat
Plain-English summary
A group of 16 cats was treated with a new topical product containing selamectin and sarolaner to see how quickly it could kill Ixodes scapularis ticks. The treatment started working within 12 hours, and by 24 hours, it completely eliminated the ticks. Even after the cats were re-infested with ticks, the treatment continued to be effective, significantly reducing tick counts for up to five weeks. There were no side effects from the treatment, making it a safe option for tick control in cats.
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Abstract
The speed of kill of a novel, topical product containing selamectin in combination with sarolaner (selamectin/sarolaner; RevolutionPlus/StrongholdPlus) was evaluated against Ixodes scapularis ticks on cats. Sixteen cats were randomly allocated to a treatment group and treated topically on Day 0 with either placebo (vehicle control) or 6 mg/kg selamectin plus 1 mg/kg sarolaner. Cats were infested with approximately 50 unfed viable adult I. scapularis ticks on Days -2, 7, 14, 21, 28 and 35. Efficacy was assessed at 4, 8, 12, 24, 48 and 72 h after treatment on Day 0 and at 4, 8, 12 and 24 h after post-treatment re-infestations. There were no adverse reactions to the topical treatment with selamectin/sarolaner. Placebo-treated cats maintained tick infestations throughout the study. Treatment with selamectin/sarolaner significantly reduced tick counts within 12 h (P < 0.0001) and resulted in 100% efficacy by 24 h. For subsequent re-infestations, live tick counts were significantly reduced by 12 h after infestation on Day 7 (P = 0.0120) and by 24 h for Days 14-35 (P < 0.0001). At 24 h after the post-treatment re-infestations, efficacy based on geometric (arithmetic) means was ≥96.1% (94.5%) through Day 21, 75.3% (67.7%) on Day 28 and 66.4% (56.4%) on Day 35. Thus, a single topical dose of RevolutionPlus/StrongholdPlus at the recommended minimum dose started killing ticks within 12-24 hours after treatment and re-infestations for up to 5 weeks. High acaricidal efficacy (≥90% reduction in tick burden) was achieved within 24 h after treatment and subsequent re-infestations for at least three weeks.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30563718/