Peer-reviewed veterinary case report
Toceranib drug showed no benefit for cats with injection site sarcoma
By Holtermann, N et al.·Published in Veterinary and comparative oncology·2017·Clinic of Small Animal Internal Medicine, Germany·View original on PubMed →
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Original publication title: The tyrosine kinase inhibitor toceranib in feline injection site sarcoma: efficacy and side effects.
- Species:
- cat
Plain-English summary
An 8-year-old domestic shorthair cat with an injection site sarcoma (a type of tumor that can develop at vaccine injection sites) was treated with a medication called toceranib, which is usually used for dog tumors. Unfortunately, the treatment did not show any measurable improvement in the tumor. However, the side effects were mostly mild and temporary, and any serious reactions were managed by taking breaks from the medication or reducing the dose.
People also search for: cat injection site sarcoma treatment · toceranib side effects in cats · feline tumor medication options
Abstract
Because of their locally invasive growth and high recurrence rate despite of aggressive local therapy, treatment of feline sarcomas is challenging. The tyrosine kinase inhibitor (TKI) toceranib is currently licensed for the treatment of canine mast cell tumours. There are only few reports about TKI usage in cats. Previous studies indicated promising potential of TKI for the treatment of feline injection site sarcoma (FISS). In this prospective clinical trial, 18 cats with unresectable FISS were treated at a target dosage of 3.25 mg kgevery other day to evaluate the clinical efficacy and toxicity of toceranib. There was no clinical response measurable. Adverse events were generally mild and temporary. Grade 3 or 4 adverse events developed infrequently and all resolved with drug holidays and dose reductions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26762970/