Peer-reviewed veterinary case report
Thienopyridine urea inhibitors of KDR kinase.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2007
- Authors:
- Heyman, H Robin et al.
- Affiliation:
- Global Pharmaceutical Research and Development · United States
Abstract
A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2, are potent inhibitors of KDR (<10 nM) in both enzymatic and cellular assays. Further characterization of inhibitor 2 indicated that this analog possessed excellent in vivo potency (ED50 2.1 mg/kg) as measured in an estradiol-induced mouse uterine edema model.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17188869/