Peer-reviewed veterinary case report
Three cases of carcinoid in the equine nasal cavity and maxillary sinuses: histologic and immunohistochemical features.
- Journal:
- Veterinary pathology
- Year:
- 1996
- Authors:
- van Maanen, C et al.
- Affiliation:
- Department of Pathology · Netherlands
- Species:
- horse
Plain-English summary
This study looked at three horses with carcinoid tumors, which are a type of tumor that can develop in the nasal cavity and sinuses. These tumors caused the horses' eyes to bulge out, a condition known as exophthalmos. The researchers found specific patterns in the tumors when they examined them under a microscope, confirming they were related to nerve cells. Interestingly, they couldn't find any normal nerve cells in the nasal area of healthy horses, so it's unclear where these tumors came from. The study highlights the unique nature of these tumors, but it doesn't provide a clear answer about their origin.
Abstract
Three cases of carcinoid tumor in horses are described. The tumors originated from the maxillary sinuses and the retrobulbar region and caused exophthalmos. Histologically, they had a characteristic endocrine pattern and were argyrophilic with the Grimelius stain. All tumors contained reactivity for neuron-specific enolase and synaptophysin. Two of three tumors were reactive for both bovine and porcine chromogranin A. These immunohistochemical results confirm the neuroendocrine nature of these tumors. Neuroendocrine cells could not be detected in the nasal mucosa and maxillary sinuses of a normal horse; therefore, the origin of these carcinoid tumors remains obscure.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/8826014/