Peer-reviewed veterinary case report
Dog develops low platelets after trimethoprim/sulfadiazine treatment
By Sullivan, P S et al.·Published in Journal of the American Veterinary Medical Association·1992·Department of Animal Science·View original on PubMed →
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Original publication title: Thrombocytopenia associated with administration of trimethoprim/sulfadiazine in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog developed low platelet counts (thrombocytopenia) after being treated with a medication called trimethoprim/sulfadiazine, which is often used for infections. The dog's condition was diagnosed using a special test that measures how well platelets are functioning. This case highlights the risk of thrombocytopenia associated with this medication. Treatment options for the dog would typically involve stopping the medication and possibly using other therapies to manage the immune response.
People also search for: dog low platelet count treatment · trimethoprim sulfadiazine side effects · dog immune-mediated thrombocytopenia
Abstract
A diagnosis of trimethoprim/sulfadiazine-induced, immune-mediated thrombocytopenia in a dog was made, using a novel in vitro assay for thrombolytic activity. The assay quantifies thrombolytic activity by measuring the amount of platelet fragments in normal canine platelets before and after incubation with plasma from the thrombocytopenic dog. This report confirms previous reports of the development of thrombocytopenia after administration of trimethoprim/sulfadiazine, and describes a new assay that, after further validation, may be useful in the diagnosis of immune-mediated thrombocytopenia when an adequate sample of platelets cannot be obtained for quantification of platelet-associated IgG.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/1293118/