Peer-reviewed veterinary case report
Best time to start chemo after limb amputation in dogs with bone
By Marconato, Laura et al.Ā·Published in Journal of the American Veterinary Medical AssociationĀ·2021Ā·View original on PubMed ā
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Original publication title: Timing of adjuvant chemotherapy after limb amputation and effect on outcome in dogs with appendicular osteosarcoma without distant metastases.
- Species:
- dog
Plain-English summary
A study involving 168 dogs with appendicular osteosarcoma (a type of bone cancer) found that starting chemotherapy within 5 days after limb amputation led to better outcomes. Dogs that received chemotherapy sooner had a longer time before the cancer progressed and lived significantly longer compared to those who started treatment later. The findings suggest that getting chemotherapy started quickly after surgery can greatly improve survival chances for dogs with this condition.
People also search for: dog bone cancer treatment Ā· osteosarcoma chemotherapy timing Ā· dog limb amputation recovery
Abstract
OBJECTIVE: To determine an optimal time interval between amputation and initiation of adjuvant chemotherapy (TI) in dogs with appendicular osteosarcoma without distant metastases and whether TIwas associated with outcome. ANIMALS: 168 client-owned dogs treated at 9 veterinary oncology centers. PROCEDURES: Data were collected from the dogs' medical records concerning potential prognostic variables and outcomes. Dogs were grouped as to whether they received chemotherapy within 3, 5, 7, 10, 15, 20, 30, or > 30 days after amputation of the affected limb. Analyses were performed to identify variables associated with time to tumor progression and survival time after limb amputation and to determine an optimal TI. RESULTS: Median TIwas 14 days (range, 1 to 210 days). Median time to tumor progression for dogs with a TI≤ 5 days (375 days; 95% CI, 162 to 588 days) was significantly longer than that for dogs with a TI> 5 days (202 days; 95% CI, 146 to 257 days). Median overall survival time for dogs with a TI≤ 5 days (445 days; 95% CI, 345 to 545 days) was significantly longer than that for dogs with a TI> 5 days (239 days; 95% CI, 186 to 291 days). CONCLUSIONS AND CLINICAL RELEVANCE: Findings indicated that early (within 5 days) initiation of adjuvant chemotherapy after limb amputation was associated with a significant and clinically relevant survival benefit for dogs with appendicular osteosarcoma without distant metastases. These results suggested that the timing of chemotherapy may be an important prognostic variable.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34516257/