Peer-reviewed veterinary case report
IgE allergy antibody levels before and after dog liver cancer surgery
By Sakakibara, Rentaro et al.·Published in The Journal of veterinary medical science·2026·School of Veterinary Medicine, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Total plasma immunoglobulin E level before and after canine hepatocellular carcinoma surgery.
- Species:
- dog
Plain-English summary
A group of dogs with liver cancer (hepatocellular carcinoma) had their blood tested for a type of antibody called immunoglobulin E (IgE) before and after surgery. While the levels of IgE were similar in healthy dogs and those with cancer, nine out of ten dogs showed a decrease in IgE levels after their surgery. This suggests that the surgery may trigger a response in the body that lowers IgE levels. More research is needed to understand this connection better, but it’s a hopeful sign that surgery could have positive effects beyond just removing the cancer.
Abstract
Immunoglobulin E (IgE) is a key mediator of allergic reactions. Recent studies have suggested that chimeric IgE targeting cancer antigens exerts anti-cancer effects. However, whether IgE production is induced endogenously in cancer-bearing hosts remains unclear. We measured total IgE concentrations in healthy dogs (n=18) and dogs with hepatocellular carcinoma (HCC; n=10) before and after surgery. IgE concentrations did not differ between the healthy and HCC groups but decreased in nine of the ten dogs after HCC surgery. Statistical analysis indicated that HCC surgery was significantly associated with reduced IgE concentrations, suggesting endogenous IgE production in response to HCC. Further investigations with larger sample sizes and measurements of cancer-antigen-specific IgE are warranted to confirm these findings.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41780948/