Peer-reviewed veterinary case report
Toward an effective targeted chemotherapy for multiple myeloma.
- Journal:
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Year:
- 2009
- Authors:
- Polson, Andrew G & Sliwkowski, Mark X
- Affiliation:
- Genentech Inc · United States
Abstract
Antibody-drug conjugates (ADCs), cytotoxic drugs chemically linked to antibodies, provide a means to increase the effectiveness of chemotherapy by targeting the drug to neoplastic cells. Anti-CD138 ADCs show promising preclinical efficacy for the treatment of multiple myeloma; however, the safety aspects of targeting CD138 have yet to be explored.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19509145/