Peer-reviewed veterinary case report
Chemotherapy side effects and survival in dogs with bone cancer
By Chun, Ruthanne et al.·Published in Journal of the American Animal Hospital Association·2005·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Toxicity and efficacy of cisplatin and doxorubicin combination chemotherapy for the treatment of canine osteosarcoma.
- Species:
- dog
Plain-English summary
A group of 35 dogs with bone cancer (osteosarcoma) had their affected limbs amputated and then received a combination of two chemotherapy drugs, cisplatin and doxorubicin, every three weeks for up to four treatments. While 16 dogs completed all four cycles, some had to stop due to side effects or because the cancer spread. On average, the dogs lived about 300 days after starting treatment, and those that survived for a year lived around 510 days. Unfortunately, this combination treatment did not show better survival rates compared to previous single-drug therapies.
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Abstract
Thirty-five dogs with appendicular osteosarcoma underwent amputation and chemotherapy with cisplatin and doxorubicin every 21 days for up to four cycles. Sixteen dogs completed all four cycles. Two dogs had therapy discontinued because of metastases. The remaining 17 dogs experienced toxicities necessitating protocol alteration or discontinuation. The median survival time of 300 days was not improved over previously reported single-agent protocols, but the 10 dogs that survived to a year lived a median of 510 days.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16267062/