Peer-reviewed veterinary case report
Macrocyclic lactone poisoning signs and treatment in dogs and cats
By Merola, Valentina M & Eubig, Paul A·Published in The Veterinary clinics of North America. Small animal practice·2018·78th Medical Group, United States·View original on PubMed →
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Original publication title: Toxicology of Avermectins and Milbemycins (Macrocyclic Lactones) and the Role of P-Glycoprotein in Dogs and Cats.
- Species:
- dog
Plain-English summary
A dog or cat that has ingested too much of certain medications called macrocyclic lactones may show serious symptoms like tremors, seizures, or even blindness. Some dogs have a genetic defect that makes them more sensitive to these drugs, meaning they can get sick from lower doses. If your pet is affected, the best treatments include immediate decontamination and supportive care, while intravenous lipid emulsion therapy might be considered, although its effectiveness isn't well established. It's crucial to get your pet to the vet right away if you suspect an overdose.
People also search for: dog seizure after medication · cat tremors treatment · macrocyclic lactone toxicity in pets
Abstract
Overdoses of macrocyclic lactones in dogs and cats can result in such signs as tremors, ataxia, seizures, coma, and blindness. Dogs with the ABCB1-1Δ gene defect are predisposed to macrocyclic lactone toxicosis at lower dosages than dogs without the defect. Intravenous lipid emulsion therapy has been suggested for treatment of macrocyclic lactone toxicosis but evidence of efficacy is limited. Initial decontamination and supportive care remain the mainstays of therapy for macrocyclic lactone toxicosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30139545/