Peer-reviewed veterinary case report
TP53 gene mutations linked to shorter survival in dogs with bone
By Kirpensteijn, Jolle et al.·Published in Veterinary surgery : VS·2008·Department of Clinical Sciences of Companion Animals and Pathobiology, Netherlands·View original on PubMed →
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Original publication title: TP53 gene mutations in canine osteosarcoma.
- Species:
- dog
Plain-English summary
A group of dogs with osteosarcoma (a type of bone cancer) was studied to see if mutations in the TP53 gene affected their survival after surgery. Out of 59 dogs, 24 had these mutations, and those with mutated genes tended to live shorter lives after their tumors were removed compared to those without mutations. Other factors, like high levels of a specific enzyme in the blood and the tumor's grade, also influenced how long the dogs survived. Understanding these genetic mutations can help veterinarians provide better care and prognosis for dogs with osteosarcoma.
People also search for: dog osteosarcoma treatment · TP53 gene mutations in dogs · dog cancer survival rates
Abstract
OBJECTIVE: To investigate mutations of the TP53 gene in canine osteosarcoma (OS). STUDY DESIGN: Clinical historic cohort study. ANIMALS: Client-owned dogs. METHODS: OS (n=59) were screened for mutations of the complete TP53 gene using polymerase chain reaction and the mutation was analyzed by single-strand conformational polymorphism. Clinical outcome of dogs with TP53-mutated OS were compared with dogs with OS without a mutation after complete surgical excision of the primary tumor. RESULTS: TP53 gene mutations were observed in 24 of 59 (40.7%) OS; 3 mutated OS had 2 mutations. The alterations consisted mainly of point mutations (74%). Dogs with mutated OS had a significantly shorter survival time (ST) after surgery than dogs with normal tumor TP53 gene expression (P=.03). Other significant prognosticators for ST and disease-free interval included elevated serum alkaline phosphatase (P<.01) and tumor grade (P=.01). CONCLUSION: TP53 genetic mutations are common in canine OS and may have a prognostic value. CLINICAL RELEVANCE: Mutations of the TP53 gene may influence survival and should be considered when evaluating canine OS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18986312/