Peer-reviewed veterinary case report
Trace mineral and antioxidant changes in dogs with demodecosis
By Beigh, S A et al.·Published in Veterinary parasitology·2013·Faculty of Veterinary Science and Animal Husbandry, India·View original on PubMed →
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Original publication title: Trace minerals status and antioxidative enzyme activity in dogs with generalized demodecosis.
- Species:
- dog
Plain-English summary
A group of dogs with generalized demodecosis, a skin condition caused by mites, showed lower levels of important trace minerals like zinc and copper compared to healthy dogs. These dogs also had higher levels of iron and signs of oxidative stress, which can harm their cells. The study found that the imbalance in these minerals and the body's ability to fight off damage might be linked to the skin condition. Addressing these deficiencies could be important for managing the health of dogs suffering from demodecosis.
People also search for: dog skin problems demodecosis treatment · why is my dog losing fur · zinc deficiency in dogs symptoms
Abstract
The present study was aimed to determine the levels of trace elements zinc, copper, iron, erythrocyte oxidant/anti-oxidant balance, vitamin C and β-carotene in dogs with generalized demodecosis. A total of 24 dogs with clinically established diagnosis of generalized demodecosis and 6 dogs as control were included in the study. In comparison to healthy control, zinc and copper levels were significantly (P<0.01) lower in dogs with generalized demodecosis, whereas iron levels were significantly (P<0.01) higher. Malondialdehyde (MDA) levels were significantly (P<0.01) higher in diseased dogs whereas activity of superoxide dismutase (SOD) and catalase were significantly (P<0.01) lower. β-carotene and vitamin C levels were significantly (P<0.05) lower in diseased dogs when compared to healthy control. SOD activity was positively correlated with zinc (rs=0.65, rs=0.71 and P<0.05) and copper (rs=0.51, rs=0.63 and P<0.05) in both healthy and diseased dogs. MDA levels were negatively correlated with iron (rs=-0.49, rs=-0.78 and P<0.05), β-carotene (rs=-0.26, P>0.05; rs=-0.54, P<0.05, respectively) in both healthy and diseased dogs and with SOD activity in diseased dogs only (rs=-0.68, P<0.05). From the present study, it was concluded that generalized demodecosis in dogs is associated with significant alteration in trace elements and oxidant/anti-oxidant imbalance and this imbalance might be secondary to changes caused by demodectic mange.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23993634/