Peer-reviewed veterinary case report
Romiplostim treatment raises platelets in 5 dogs with immune
By Kohn, Barbara et al.·Published in BMC veterinary research·2016·FB Veterinä, Germany·View original on PubMed →
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Original publication title: Treatment of 5 dogs with immune-mediated thrombocytopenia using Romiplostim.
- Species:
- dog
Plain-English summary
Five dogs suffering from a serious condition called immune-mediated thrombocytopenia (ITP), which causes low platelet counts and can lead to bleeding, were treated with a medication called Romiplostim. This treatment was given weekly, and all five dogs showed an increase in their platelet counts. Remarkably, four out of the five dogs went into remission and did not experience any relapses during the follow-up period of 3 to 10 months. This suggests that Romiplostim could be a promising option for treating ITP in dogs.
People also search for: dog immune-mediated thrombocytopenia treatment · Romiplostim for dogs · dog low platelet count symptoms
Abstract
BACKGROUND: Immune thrombocytopenia (ITP) in dogs is analogous to that in humans. Romiplostim, a novel thrombopoietin receptor (TPO-R) agonist, is currently used for the treatment of refractory ITP in humans, but not in dogs. Here, we describe the response to romiplostim in five dogs with refractory ITP. Five dogs with severe and refractory ITP (three primary and two secondary) received romiplostim subcutaneously. Four dogs were administered 3-5 μg/kg and one dog received 10-13 μg/kg body weight once weekly. RESULTS: Romiplostim was well-tolerated and administration was associated with an increase in platelet counts in all five dogs. Four of the five dogs entered remission and relapses were not observed over a follow-up period of 3-10 months. CONCLUSIONS: Romiplostim is effective in the treatment of ITP in dogs at least as well as in humans. This finding may help to develop and use new therapeutics for ITP in dogs and humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27283401/