Peer-reviewed veterinary case report
Two dogs with T-zone lymphoma treated with chlorambucil
By Heetae Park et al.·Published in Korean Journal of Veterinary Research·2023·View original on Semantic Scholar →
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Original publication title: Treatment of canine CD3+/CD21+/CD45- T-zone lymphoma with chlorambucil and prednisolone in two dogs: case reports
- Species:
- dog
Plain-English summary
Two dogs with T-zone lymphoma, a slow-growing type of cancer, were brought to the vet because they had swollen lymph nodes and one had noticeable lesions on its tongue. Tests confirmed the diagnosis, and the dogs were treated with a combination of chlorambucil, a chemotherapy drug, and prednisolone, a steroid. Both dogs showed improvement in their condition without any negative side effects from the treatment. This suggests that chlorambucil can be a good option for managing T-zone lymphoma in dogs.
People also search for: dog lymphoma treatment · chlorambucil for dogs · swollen lymph nodes in dogs
Abstract
Canine T-zone lymphoma (TZL) is an indolent form of T-cell lymphoma. Conservative management is usually recommended; however, chemotherapy may be considered for symptomatic or progressive cases. Herein, we describe two dogs with generalized peripheral lymphadenopathy and peripheral blood lymphocytosis at presentation. One dog presented with gross lesions on the tongue. Flow cytometric immunophenotyping and cytological examinations demonstrated findings consistent with those of TZL. Chemotherapy with chlorambucil and prednisolone was administered, which resulted in improvement of the condition without any adverse events. Chemotherapy with chlorambucil may be considered as an appropriate choice for treating canine TZL.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/a90b0330039e6fc4d3ebc96884db22b6b70bf4e7