Peer-reviewed veterinary case report
Treatment of skin leishmaniasis in dogs with furazolidone
By Marcos Santos Zanini et al.·Published in Veterinaria Italiana·2023·Department of Veterinary Medicine, Federal University of Espírito Santo (UFES), Campus Alegre, 29.500-000 Alegre, Espírito Santo, Brazil, IT·View original on DOAJ →
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Original publication title: Treatment of canine cutaneous leishmaniasis by Leishmania (Viannia) braziliensis in dogs with furazolidone and β-cyclodextrin: case report.
- Species:
- dog
Plain-English summary
Nine dogs with skin sores caused by a parasite called Leishmania (Viannia) braziliensis were treated with a combination of furazolidone and β-cyclodextrin. These dogs, aged 3 to 10 years and weighing between 4 to 17 kg, had ulcerous lesions on areas like their scrotum, ears, and nostrils. After starting treatment, the sores began to heal within 35 to 41 days. Over a follow-up period of fourteen months, none of the dogs showed any signs of the sores returning or the parasite growing back. This treatment proved effective for managing the skin issues caused by this parasite in dogs.
People also search for: dog skin sores treatment · Leishmania braziliensis in dogs · furazolidone for dog skin problems
Abstract
Euthanasia of animals is not accepted as a control for cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis and drugs used in humans for the treatment of leishmaniasis are not allowed for animals in Brazil. Miltefosine was authorized for dogs infected by Leishmania infantum with variable results for L. braziliensis. Thus, nine dogs infected with Leishmania (V.) braziliensis were treated by a combination of furazolidone and β-cyclodextrin. The nine dogs were mongrels, weighing between 4-17 kg and 3-10 years old. These dogs had ulcerous lesions in different regions such as scrotal tissue, auricular pavilion and nostrils. Serological, molecular and protozoal culture techniques were used for laboratory diagnosis. The treatment used furazolidone + β-cyclodextrin complex (1: 2) at a concentration of 60 mg/mL given orally at a dose of 15 mg/kg every 12 hours. The re-epithelialization of lesions occurred between 35 and 41 days of treatment. During fourteen months the animals were monitored and there was no reactivation of lesions or growth of the protozoan in a culture medium of the biopsies. This study demonstrated that treatment with FZD and CD is effective in reducing the cutaneous lesions caused by L. braziliensis in dogs.
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Search related cases →Original publication on DOAJ: https://doi.org/10.12834/VetIt.2239.15416.2