Peer-reviewed veterinary case report
Spot-on moxidectin and imidacloprid treat dog mite infection
By Huang, Hui-Pi & Lien, Yu-Hsin·Published in Acta veterinaria Scandinavica·2013·View original on PubMed →
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Original publication title: Treatment of canine generalized demodicosis associated with hyperadrenocorticism with spot-on moxidectin and imidacloprid.
- Species:
- dog
Plain-English summary
A group of dogs with generalized demodicosis (a skin condition caused by mites) related to hyperadrenocorticism (Cushing's disease) were treated with a weekly spot-on medication containing moxidectin and imidacloprid. Before treatment, these dogs had a high number of mites, but after 12 weeks of treatment, most had no detectable mites and showed significant improvement in their skin condition. Out of 11 dogs, 10 achieved complete recovery and remained healthy for a year after treatment. This combination therapy proved to be both effective and safe for these dogs.
People also search for: dog skin problems treatment · moxidectin for dogs · Cushing's disease in dogs · demodicosis in dogs treatment
Abstract
BACKGROUND: Canine generalized demodicosis associated with hyperadrenocorticism is often problematic and might be intractable. The aim of this study was to report the efficacy of a weekly application of spot-on moxidectin/imidacloprid in dogs with hyperadrenocorticism and secondary generalized demodicosis. METHODS: Dogs with hyperadrenocorticism and secondary generalized demodicosis were included. The condition of hyperadrenocorticism was treated and stabilized with trilostane before and throughout the study period in all dogs. RESULTS: Average total live adult mite counts before treatment and after four, eight and 12 weeks of spot-on moxidectin/imidacloprid (2.5/10 mg/kg) applications were 20.1±6.3 (range, 13-33), 0.5±0.7 (range, 0-2; 6/11 were negative), 0.2±0.4 (range, 0-1; 9/11 were negative), 0.2±0.4 (range, 0-1; 9/11 were negative) and 0.1±0.3 (range, 0-1; 10/11 were negative) respectively; this difference was significant (P<0.001). Ten of 11 dogs (90.1%) achieved clinical remission, as demonstrated by the absence of demodectic mites at any life stage at monthly scrapings for eight consecutive weeks, and maintained remission throughout the 12-month follow-up period. CONCLUSION: The weekly application of spot-on moxidectin/imidacloprid appeared to be effective and safe against generalized adult onset canine demodicosis associated with hyperadrenocorticism.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23663380/