Peer-reviewed veterinary case report
Weekly doramectin injections to treat severe dog skin disease
By Hutt, John H C et al.·Published in Veterinary dermatology·2015·Dermatology for Animals, Australia·View original on PubMed →
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Original publication title: Treatment of canine generalized demodicosis using weekly injections of doramectin: 232 cases in the USA (2002-2012).
- Species:
- dog
Plain-English summary
A group of dogs with a severe skin condition called generalized demodicosis (a type of mite infestation) received weekly injections of a medication called doramectin. Out of 232 dogs treated, nearly all (94.8%) showed significant improvement and went into remission after an average of about 7 weeks of treatment. The injections were generally well-tolerated, with very few side effects reported. This suggests that doramectin is an effective option for treating this challenging skin disease in dogs.
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Abstract
BACKGROUND: Generalized demodicosis is a severe skin disease in the dog, with limited treatment options. HYPOTHESIS/OBJECTIVES: To demonstrate that doramectin, when given at a dose rate of 0.6 mg/kg body weight, is a safe and effective treatment for generalized demodicosis in the dog. ANIMALS: Four hundred client-owned dogs diagnosed with generalized demodicosis at one general small-animal practice. Of these, 232 completed their treatment and were included in the study. METHODS: A retrospective study was carried out by searching the computerised medical records of dogs seen at one general small-animal practice in Tennessee, USA. The records of each dog with a diagnosis of generalized demodicosis, who underwent treatment using weekly injections of doramectin at a dose rate of 0.6 mg/kg body weight, were analysed. RESULTS: Remission was achieved in 94.8% of dogs treated with weekly subcutaneous injections of doramectin at a dose rate of 0.6 mg/kg body weight. Adverse events were rare with two suspected instances (0.5%) being recorded. The mean duration of treatment was 7.1 weeks. CONCLUSIONS AND CLINICAL IMPORTANCE: Doramectin given at a dose rate of 0.6 mg/kg body weight by subcutaneous injection at weekly intervals is a useful and well-tolerated treatment for generalized demodicosis in the dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26190685/