Peer-reviewed veterinary case report
Treatment results for lymphoma in 75 dogs using COPLA and LVP
By Boyce, KL & Kitchell, BE·Published in Journal of the American Animal Hospital Association·2000·View original on Crossref →
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Original publication title: Treatment of canine lymphoma with COPLA/LVP
- Species:
- dog
Plain-English summary
Seventy-five dogs diagnosed with lymphoma were treated with a combination of chemotherapy drugs, including L-asparaginase and doxorubicin, followed by a maintenance regimen. About 80% of the dogs had a complete response to the treatment, meaning their cancer went into remission, while 12% had a partial response. The dogs that achieved complete remission lived a median of 36 weeks longer, compared to just four weeks for those with partial or no response. The treatment was generally well-tolerated with low toxicity levels.
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Abstract
Seventy-five dogs with cytopathologically or histopathologically confirmed lymphoma received L-asparaginase, vincristine, cyclophosphamide, prednisone, and doxorubicin (COPLA) induction followed by chlorambucil, vincristine, and prednisone (LVP) maintenance between January 1994 and June 1997. Toxicity was evaluated using the National Cancer Institute (NCI) toxicity criteria. Age, weight, sex, and response were evaluated for prognostic significance against first remission duration. A complete response (CR) was obtained in 61 (80%) dogs, a partial response (PR) was obtained in nine (12%) dogs, and no response (NR) was obtained in five (8%) dogs. The median first remission duration was 25 weeks, with 17% and 5% of the dogs in remission at one and two years, respectively. Observed toxicity was low, with 84% of dogs given an NCI score of 1 or 2. Median survival time for dogs achieving CR was 36 weeks versus four weeks for those achieving PR or NR.
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Search related cases →Original publication on Crossref: https://doi.org/10.5326/15473317-36-5-395