Peer-reviewed veterinary case report
Dogs with chronic lymphocytic leukemia treated successfully
By Fujino, Y et al.·Published in The Journal of small animal practice·2004·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Treatment of chronic lymphocytic leukaemia in three dogs with melphalan and prednisolone.
- Species:
- dog
Plain-English summary
Three adult dogs diagnosed with chronic lymphocytic leukemia (CLL) showed improvement after being treated with melphalan and prednisolone. The dogs had different types of CLL, with two having B cell CLL and one possibly having T cell CLL. After starting treatment, their clinical signs and blood abnormalities improved over a period of eight to 210 days, and they experienced only mild side effects. This combination of medications appears to be effective in helping dogs with CLL achieve remission with minimal adverse effects.
People also search for: dog leukemia treatment · melphalan for dogs · prednisolone side effects in dogs
Abstract
Three adult dogs with chronic lymphocytic leukaemia (CLL) were successfully treated with melphalan and prednisolone. Based on the immunophenotypic analysis of leukaemic cells, two dogs were diagnosed with B cell CLL and one dog was tentatively diagnosed as having T cell CLL. One dog with B cell CLL had IgM monoclonal gammopathy. The clinical signs and haematological abnormalities associated with CLL in the three dogs improved with the administration of cytoreductive melphalan (3 to 5 mg/m2/day) and prednisolone (4.3 to 30 mg/m2/day) for eight to 210 days. There were no severe adverse effects except a mild increase in plasma alkaline phosphatase activity. Melphalan and prednisolone therapy may achieve remission with few side effects in dogs with CLL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15206475/