Peer-reviewed veterinary case report
Diabetic dog with Evans syndrome treated with immunoglobulin
By Bianco, Domenico & Hardy, Robert M·Published in Journal of the American Animal Hospital Association·2009·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Treatment of Evans' syndrome with human intravenous immunoglobulin and leflunomide in a diabetic dog.
- Species:
- dog
Plain-English summary
An 11-year-old spayed female miniature schnauzer with diabetes was diagnosed with Evans' syndrome, a condition that affects blood cell production. To avoid the side effects of steroids, the veterinarian treated her with a single infusion of human intravenous immunoglobulin and oral leflunomide. This approach led to complete remission of her condition, and after 10 months, the leflunomide was stopped. Over the next 19 months, the dog did not have any relapses and continued to manage her diabetes well.
People also search for: miniature schnauzer Evans' syndrome treatment · dog diabetes management · leflunomide for dogs
Abstract
An 11-year-old, spayed female miniature schnauzer with diabetes mellitus was presumptively diagnosed with Evans' syndrome (ES). Because of the potential adverse effects of immunosuppressive doses of glucocorticoids in a diabetic dog, a single infusion of human intravenous immunoglobulin and oral leflunomide were used as first-line immunomodulatory therapy, after informed owner consent was received. This treatment resulted in complete remission of the ES, and leflunomide was discontinued after 10 months of therapy. Over a 19-month follow-up, the dog did not relapse and has remained a well-regulated diabetic.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19411652/