Peer-reviewed veterinary case report
Treating small-cell gut lymphoma in cats with chlorambucil
By Stein, Timothy J et al.·Published in Journal of the American Animal Hospital Association·2010·School of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Treatment of feline gastrointestinal small-cell lymphoma with chlorambucil and glucocorticoids.
- Species:
- cat
Plain-English summary
A group of 28 cats diagnosed with small-cell gastrointestinal lymphoma (a type of cancer affecting the intestines) were treated with a combination of chlorambucil (a chemotherapy drug) and glucocorticoids (steroids). Most of the cats responded well to this treatment, with a remarkable 96% showing improvement and a median remission lasting about 2 years. For those that relapsed, a different treatment using cyclophosphamide (another chemotherapy) and glucocorticoids was effective, with all of them responding positively. Overall, this approach provided significant benefits for cats suffering from this condition.
People also search for: cat gastrointestinal lymphoma treatment · chlorambucil for cats · cat cancer remission duration
Abstract
Gastrointestinal (GI) lymphoma is the most frequently diagnosed form of lymphoma in the cat and is categorized into two distinct forms based on the size of neoplastic lymphocytes. Treatments for both large- and small-cell GI lymphoma have been described previously; however, multiple chemotherapy protocols were used, a minimal amount of histopathological characterization was provided, and, in most studies, the majority of diagnoses were obtained via endoscopic pinch biopsies. Twenty-eight cats (24 with full-thickness intestinal biopsies) were diagnosed with small-cell GI lymphoma and treated with a combination of chlorambucil and glucocorticoids. The majority of cases were strongly CD3+, and many displayed epitheliotropism. The overall clinical response rate was 96%, with a median clinical remission duration of 786 days. Follow-up identified seven cats with relapsed disease-all of which were treated with a rescue protocol of cyclophosphamide and glucocorticoids; the response rate was 100%, and four of the 28 cats were diagnosed with a second malignancy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21041334/