Peer-reviewed veterinary case report
Chemotherapy outcomes for cats with intermediate to high-grade
By Collette, S A et al.·Published in Veterinary and comparative oncology·2016·Veterinary Medical Teaching Hospital, United States·View original on PubMed →
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Original publication title: Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012).
- Species:
- cat
Plain-English summary
A group of 119 cats diagnosed with intermediate- to high-grade lymphoma underwent a modified chemotherapy treatment called the University of Wisconsin-Madison protocol. The study found that cats who responded completely to the treatment lived significantly longer and had better quality of life compared to those with partial or no response. On average, cats that achieved a complete response had a median survival time of about 318 days, while those with no response survived only around 27 days. This suggests that the modified chemotherapy can be effective, especially for those who respond well to it.
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Abstract
CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free CHOP-based protocols have been published and readily used in dogs, there is limited literature regarding similar maintenance-free protocols in cats. The purpose of this study was to describe the outcome of cats with intermediate- to high-grade lymphoma that were prescribed a modified 25-week University of Wisconsin-Madison (UW-25) chemotherapy protocol. A secondary objective was examination of potential prognostic factors. One hundred and nineteen cats from five institutions treated with a UW-25-based protocol were included. The Kaplan-Meier median progression-free interval (PFI) and survival time (MST) were 56 and 97 (range 2-2019) days, respectively. Cats assessed as having a complete response (CR) to therapy had significantly longer PFI and MST than those with partial or no response (PFI 205 versus 54 versus 21 days, respectively, P < 0.0001 and MST 318 versus 85 versus 27 days, respectively, P < 0.0001).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26109275/