Peer-reviewed veterinary case report
Mycophenolate mofetil alone cured immune platelet loss in five dogs
By Yau, V K & Bianco, D·Published in The Journal of small animal practice·2014·Pasadena Veterinary Specialists, United States·View original on PubMed →
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Original publication title: Treatment of five haemodynamically stable dogs with immune-mediated thrombocytopenia using mycophenolate mofetil as single agent.
- Species:
- dog
Plain-English summary
Five dogs with low platelet counts due to immune-mediated thrombocytopenia (a condition where the immune system attacks platelets) were treated with a medication called mycophenolate mofetil instead of corticosteroids, which can have side effects. After stopping their previous pain medications, all dogs responded well to the new treatment and showed complete recovery. Four of the dogs were able to stop the medication after a few months without any relapses, while one dog needed to continue treatment to stay healthy. Some dogs experienced mild side effects like diarrhea and decreased appetite, but overall, the treatment was successful.
People also search for: dog low platelet count treatment · immune-mediated thrombocytopenia in dogs · mycophenolate mofetil side effects in dogs
Abstract
Five dogs were presumptively diagnosed with immune-mediated thrombocytopenia. As they had all been chronically treated with non-steroidal anti-inflammatory drugs, administration of immunosuppressive doses of corticosteroids was considered contraindicated. Non-steroidal anti-inflammatory drugs were temporarily discontinued in all the dogs and mycophenolate mofetil was introduced as first-line single immunomodulatory therapy. This treatment protocol resulted in complete remission of immune-mediated thrombocytopenia in all the dogs, and mycophenolate mofetil was discontinued after several months of therapy in four of the five dogs with no relapses, even when non-steroidal anti-inflammatory drug administration was resumed. The remaining dog required continued mycophenolate mofetil therapy to avoid relapse. One dog experienced diarrhoea, and another dog had diarrhoea and decreased appetite.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24602067/