Peer-reviewed veterinary case report
Dog with kidney disease and swelling treated with thromboxane
By Grauer, G F et al.·Published in Journal of veterinary internal medicine·1992·Department of Medical Sciences·View original on PubMed →
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Original publication title: Treatment of membranoproliferative glomerulonephritis and nephrotic syndrome in a dog with a thromboxane synthetase inhibitor.
- Species:
- dog
Plain-English summary
A 2-year-old spayed female Whippet was brought in for swelling in her abdomen and legs, symptoms of nephrotic syndrome caused by a kidney condition called membranoproliferative glomerulonephritis. She was treated with a medication that inhibits thromboxane synthetase, which helped reduce protein in her urine and resolved the swelling. However, when the treatment was stopped for 10 weeks, her symptoms returned, but improved again once the medication was restarted. This treatment shows promise for dogs with similar kidney issues.
People also search for: dog kidney disease treatment · Whippet nephrotic syndrome · dog protein in urine treatment
Abstract
A 2-year-old spayed female Whippet with membranoproliferative glomerulonephritis and nephrotic syndrome was treated with a specific thromboxane synthetase inhibitor (3-methyl-2[3-pyridyl]-1-indoleoctanoic acid), resulting in decreased proteinuria and resolution of ascites and edema. Glomerular histology, however, appeared unaffected by treatment. Discontinuation of treatment for 10 weeks resulted in increased proteinuria and decreased serum albumin concentrations that were again attenuated when treatment was reinitiated. Thromboxane synthetase inhibitors have been used successfully to treat experimentally induced glomerulonephritis in several species and this treatment appears to hold promise for naturally occurring glomerulonephritis in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/1588545/