Peer-reviewed veterinary case report
Felbamate treatment reduces partial seizures in six dogs
By Ruehlmann, D et al.·Published in The Journal of small animal practice·2001·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Treatment of partial seizures and seizure-like activity with felbamate in six dogs.
- Species:
- dog
Plain-English summary
Six dogs with partial seizures were treated with the medication felbamate, which helped reduce the number of seizures they experienced. The dogs, aged between four months and eight years, had been having seizures for up to three years before starting treatment. After beginning felbamate, all dogs showed a decrease in seizure frequency, with some even stopping seizures completely. While two dogs had some temporary side effects, the overall results suggest that felbamate is a safe and effective option for managing partial seizures in dogs.
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Abstract
Six dogs with partial seizures or partial seizure-like activity were treated with the antiepileptic drug felbamate between 1993 and 1998. All dogs had a history and results of diagnostic testing suggestive of either primary (idiopathic) or occult secondary epilepsy. Dogs ranged between four months and eight years of age at the onset of seizure activity. The median time period between onset of the first seizure and the start of felbamate therapy was 3.8 months (range 0.75 to 36 months). Median duration of therapy was nine months (range two to 22 months). All dogs experienced a reduction in seizure frequency after felbamate administration. Median total number of seizures post-treatment was two (range 0 to 9). Two dogs had an immediate and prolonged cessation of seizure activity. Steady-state trough serum felbamate concentrations measured at two weeks, and one, 12 and 22 months after the commencement of therapy in four dogs ranged between 13 and 55 mg/litre (median 35 mg/litre). Reversible haematological adverse effects were detected in two dogs, with one dog developing concurrent keratoconjunctivitis sicca. These results suggest that felbamate can be an effective antiepileptic drug without life-threatening complications when used as monotherapy for partial seizures in the dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11518421/