Peer-reviewed veterinary case report
Dog with head skin tumor made of epithelial and plump stromal cells
By Mineshige, Takayuki et al.·Published in The Journal of veterinary medical science·2014·Research Institute of Biosciences, Japan·View original on PubMed →
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Original publication title: Trichoblastoma with abundant plump stromal cells in a dog.
- Species:
- dog
Plain-English summary
An 11-year-old female mixed-breed dog had a tumor on her head that was examined by a vet. The tumor was well-defined and made up of abnormal skin cells, surrounded by a type of supportive tissue. Tests showed that the tumor cells had specific markers, indicating they were neoplastic (cancerous). The supportive cells were also found to be actively growing near the tumor cells, suggesting they were interacting closely. The dog was likely treated based on the findings, but the outcome isn't specified in the abstract.
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Abstract
Histopathological and immunohistochemical examinations were made on a cutaneous tumor on the head of an 11-year-old female mixed-breed dog. The tumor was well demarcated and comprised multilobular structures of neoplastic epithelial cells with abundant plump peritumoral stromal cells. The neoplastic cells formed irregular cell cords or trabeculae and were arranged in characteristic palisades at the periphery. Immunohistochemically, neoplastic cells were positive for p63 and the several cytokeratins examined. In contrast, the plump peritumoral stromal cells were positive for vimentin and unevenly for nestin, a neuroepithelial stem cell protein. The stromal cells prominently proliferated in proximity to epithelial neoplastic cells, suggesting a close interaction between these two cell types.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24430656/