Peer-reviewed veterinary case report
Tryptophan-deficient diet increases the neurochemical and behavioral response to amphetamine.
- Journal:
- Brain research
- Year:
- 2006
- Authors:
- Carta, Manolo et al.
- Affiliation:
- Department of Sciences Applied for Biosystems · Italy
- Species:
- rodent
Abstract
The present study examined the effects of a tryptophan-deficient diet on behavioral and neurochemical response to amphetamine. A tryptophan-deficient diet (14 days) decreased striatal serotonin and 5-hydroxyindolacetic acid content in rats. Under the latter conditions, amphetamine increased dopamine efflux in striatum and nucleus accumbens and produced a greater increase in motor activity when compared to controls. These results indicate how response to psychostimulants might be altered in the presence of a tryptophan-deficient diet.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16729986/