Peer-reviewed veterinary case report
Beagle dog diagnosed with lymphoma and leukemia at once
By Ferrari, Alessandro et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2021·Clinica Veterinaria San Lorenzo, Italy·View original on PubMed →
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Original publication title: Tumor staging in a Beagle dog with concomitant large B-cell lymphoma and T-cell acute lymphoblastic leukemia.
- Species:
- dog
Plain-English summary
An 8-year-old spayed female Beagle was brought in because her lymph nodes were swollen. Tests showed she had large B-cell lymphoma, a type of cancer, and also suspected T-cell acute lymphoblastic leukemia, another serious condition. Despite receiving multi-agent chemotherapy, she sadly passed away 46 days after her diagnosis. This case highlights the importance of accurate tumor staging and classification to help determine the best treatment options and prognosis for dogs with complex cancers.
People also search for: Beagle lymphoma treatment · dog swollen lymph nodes · dog leukemia symptoms · chemotherapy for dog cancer · dog cancer prognosis
Abstract
An 8-y-old spayed female Beagle dog was presented with peripheral lymphadenomegaly. Lymph node cytology and flow cytometry led to the diagnosis of large B-cell lymphoma (LBCL). We detected minimal percentages of LBCL cells in peripheral blood and bone marrow samples. However, a monomorphic population of neoplastic cells different from those found in the lymph node was found in the bone marrow. T-cell acute lymphoblastic leukemia was suspected based on flow cytometric immunophenotyping. PCR for antigen receptor rearrangement (PARR) revealed clonal rearrangement of both B-cell and T-cell receptors, and the presence of both neoplastic clones in the lymph node, peripheral blood, and bone marrow. The dog was treated with multi-agent chemotherapy but died 46 d following diagnosis. Tumor staging and patient classification are needed to accurately establish a prognosis and select the most appropriate therapeutic protocol.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33884946/