Peer-reviewed veterinary case report
Boxer dog with progressive neurological signs
By Kuwamura, M et al.·Published in Acta neuropathologica·1993·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Type C Niemann-Pick disease in a boxer dog.
- Species:
- dog
Plain-English summary
A 9-month-old Boxer was brought to the vet due to worsening neurological issues, which included problems with movement and coordination. Tests showed that the dog had a serious condition similar to Niemann-Pick disease, a genetic disorder that leads to harmful fat buildup in the body. The vet found high levels of certain fats in the dog's liver and brain, indicating a severe lipid storage disease. Unfortunately, this condition is progressive and currently has no cure, so the focus would be on managing symptoms and providing supportive care.
People also search for: Boxer dog neurological problems · Niemann-Pick disease in dogs · dog lipid storage disease symptoms
Abstract
Pathological and biochemical studies were performed on a 9-month-old boxer dog with progressive neurological abnormality. Histological examination revealed marked neuronal storage throughout the central nervous system and histiocytic storage in the reticuloendothelial system. Ultrastructurally, the neuronal storage consisted of accumulation of concentric membranous inclusions and clusters of dense bodies. The biochemically unesterified cholesterol content was high in the liver and spleen. The brain showed increased levels of lactosylceramide and two gangliosides, GM3 and GM2. These findings indicate that this dog was affected with a heterogeneous lipid storage disease similar to the human Niemann-Pick type C disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8460536/