Peer-reviewed veterinary case report
Dog diagnosed with clear cell sarcoma - what it means
By Cangul, I T et al.·Published in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·1999·Department of Pathology, Netherlands·View original on PubMed →
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Original publication title: Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case.
- Species:
- dog
Plain-English summary
A 9-year-old mixed-breed dog was diagnosed with a rare type of cancer called clear cell sarcoma, which is similar to a form of malignant melanoma. The tumor was found to have characteristics of melanocytes, the cells that produce pigment, and tests showed that a specific gene related to these cells was active. This case is significant as it is the first reported instance of this type of tumor in dogs, highlighting the need for awareness of similar tumors in pets. Treatment options would typically involve surgery and possibly chemotherapy, but specific outcomes were not detailed in the study.
People also search for: dog cancer symptoms · clear cell sarcoma in dogs · melanoma treatment for dogs
Abstract
The aim of this study was to characterize a metastasizing soft tissue tumor in a dog, which clinically, grossly and histologically showed a close resemblance to human clear cell sarcoma, a soft tissue variant of malignant melanoma. Ultrastructurally, melanosomes were found, indicating a melanocytic origin of the tumor. Using reverse-transcription polymerase chain reaction, expression of the gene encoding tyrosinase was determined in tumor cells. With this first case of canine clear cell sarcoma, as well as the earlier report from our laboratory on amelanotic melanomas in the cat, we demonstrate that expression of the tyrosinase gene may occur in a broader range of less differentiated melanocytic tumors in different species, including man.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10598869/