Peer-reviewed veterinary case report
Understanding the molecular basis of disease is crucial to improving the design and construction of herpesviral vectors for veterinary vaccines.
- Journal:
- Vaccine
- Year:
- 2015
- Authors:
- Mahony, T J
- Affiliation:
- The University of Queensland · Australia
Plain-English summary
This research discusses how viral infections, like Marek's disease in chickens and bovine respiratory disease in cattle, can lead to significant losses in animal farming. While vaccines are available to help control these diseases, they continue to be major problems. The study looks at how certain viruses from the herpes family both cause and can be used to help control these diseases. It also explores new technologies that could lead to better vaccines for more effective and sustainable management of Marek's disease and bovine respiratory disease. Overall, the goal is to improve vaccine design to better protect animals from these infections.
Abstract
Viral infections are associated with production losses in many animal production industries. Important examples of this are Marek's disease (MD) and bovine respiratory disease (BRD) which are significant issues in the chicken and cattle industries, respectively. Viruses play key roles in MD and BRD development and consequently have also been utilised in vaccination strategies to control these diseases. Despite the widespread availability and use of vaccines to control these diseases both are still major issues for their respective industries. Here the dual role of members of viruses from the family Herpesviridae in causation and control of MD and BRD will be discussed. The technologies that may lead to the development of improved vaccines to provide more sustainable control of MD and BRD will also be identified.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26387436/