Peer-reviewed veterinary case report
Dog with blood in urine diagnosed with urachal bladder cancer
By Shrader, S et al.·Published in Journal of comparative pathology·2016·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Urachal Adenocarcinoma in a Dog.
- Species:
- dog
Plain-English summary
An 8-year-old neutered female Labrador retriever was brought to the vet because she had been experiencing blood in her urine for three years. An ultrasound of her bladder showed a small mass, which was surgically removed. After examining the mass, the vet diagnosed it as urachal adenocarcinoma, a rare type of cancer originating from the urachus, a structure connected to the bladder. This case is significant as it's the first reported instance of this type of cancer in a dog.
People also search for: dog blood in urine · Labrador retriever cancer treatment · urachal adenocarcinoma in dogs
Abstract
An 8-year-old neutered female Labrador retriever was presented with a 3-year history of intermittent haematuria. Ultrasonographic evaluation of the urinary bladder revealed a 2 × 3 × 0.5 cm intraluminal mass arising at the dome. The mass was excised via partial cystectomy. Histopathological examination revealed neoplastic epithelial cells arranged in sheets, irregularly-branching tubules and acini within a fibrovascular stroma. Neoplastic cells were cuboidal to polygonal with abundant foamy amphophilic cytoplasm, typically with a single, large, clear intracytoplasmic vacuole and eccentric nucleus ('signet ring' cells). Neoplastic tubules were often ectatic and contained abundant mucin. Immunohistochemically, the neoplastic cells had weak, cytoplasmic immunoreactivity for cytokeratin 7 and rare, but strong, nuclear immunoreactivity for CDX2. Based on the cellular morphology, immunolabelling characteristics and anatomical location, a diagnosis of adenocarcinoma of urachal origin was made. To the authors' knowledge, this is the first reported case of urachal adenocarcinoma in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27009748/