Peer-reviewed veterinary case report
Urinary clusterin as a kidney damage marker in dogs with leishmaniasis
By García-Martínez, Juan D et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2012·Department of Animal Surgery and Medicine, Spain·View original on PubMed →
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Original publication title: Urinary clusterin as a renal marker in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with leishmaniasis (a disease caused by parasites) was tested for kidney damage using a new urine test that measures a protein called clusterin. Out of 75 dogs, those with more severe kidney issues showed higher levels of clusterin in their urine compared to healthy dogs. This suggests that measuring urinary clusterin could help veterinarians detect kidney problems earlier in dogs. The study indicates that this test might be a useful tool for identifying chronic kidney disease in dogs before it becomes severe.
People also search for: dog kidney disease symptoms · leishmaniasis in dogs · urinary clusterin test for dogs
Abstract
A validation of a species-specific enzyme immunoassay for urinary clusterin measurement in dogs was performed, and the use of urinary clusterin as a marker of renal damage was evaluated in a population of dogs with leishmaniasis. Urine was obtained from 75 dogs; 64 dogs had leishmaniasis and 11 were healthy. The dogs with leishmanias were divided into 5 groups: I (n = 9; serum creatinine [SCr] < 1.4 mg/dl, urinary protein-to-creatinine [UPC] ratio ≤ 0.5); II (n = 29; SCr < 1.4 mg/dl, UPC > 0.5); III (n = 6; SCr ≥ 1.4 mg/dl to <2 mg/dl, UPC > 0.5); IV (n = 13; SCr ≥ 2 mg/dl to <5 mg/dl, UPC > 0.5); and V (n = 7; SCr ≥ 5 mg/dl, UPC > 0.5). The urinary clusterin concentration was measured, and the urinary clusterin-to-creatinine ratio was calculated. Canine urinary clusterin assay showed good analytical performance based on precision accuracy and limit-of-detection results. There was a statistically significant increase in urinary clusterin and clusterin-to-creatinine ratio in groups II-V compared with group I and healthy group. The results of the current study showed that urinary clusterin concentration and urinary clusterin-to-creatinine ratios are increased in dogs with analytical evidences of renal damage and that the urinary clusterin-to-creatinine ratio might be used as a potential early biomarker of chronic kidney disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22362533/