Peer-reviewed veterinary case report
Calcium and phosphate urine levels in dogs with pituitary
By Fracassi, F et al.·Published in The Veterinary record·2015·Department of Veterinary Medical Sciences, Italy·View original on PubMed →
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Original publication title: Urinary excretion of calcium and phosphate in dogs with pituitary-dependent hypercortisolism: case control study in 499 dogs.
- Species:
- dog
Plain-English summary
A group of dogs with pituitary-dependent hypercortisolism (PDH) were found to have higher levels of phosphate in their blood compared to healthy dogs. This condition can lead to various health issues, and the study looked at how PDH affects calcium and phosphate levels in urine. The results showed that dogs with PDH had lower amounts of phosphate in their urine but higher amounts of calcium. These findings suggest that the kidneys may be holding onto phosphate more than they should in dogs with PDH.
People also search for: dog high phosphate levels · pituitary-dependent hypercortisolism treatment · dog kidney health · calcium levels in dogs · dog urine tests for phosphate
Abstract
Pituitary-dependent hypercortisolism (PDH) in dogs is frequently associated with high serum phosphate and parathormone concentrations which are in turn associated with prognosis and clinical presentation. The pathogenesis of such abnormalities remains unknown. The aim of the present study was to evaluate the serum and urinary concentrations and the urinary fractional excretion of phosphate and calcium in dogs with PDH. Medical records of newly diagnosed PDH dogs before treatment from one referral centre were retrospectively evaluated. One clinically normal and one sick dog for each dog with PDH were included as controls. One hundred and sixty-seven dogs with PDH were included. The serum phosphate concentration in PDH dogs was significantly (P<0.0001) higher compared with clinically normal control dogs (CNDs) and sick control dogs (SCDs). The serum calcium concentration in PDH dogs was significantly higher compared with SCDs but not different compared with CNDs. Urinary fractional excretion of phosphate in PDH dogs was significantly lower compared with CNDs and SCDs. Urinary fractional excretion of calcium in PDH dogs was significantly higher compared with CNDs and SCDs. In conclusion, PDH dogs have lower phosphaturia and higher calciuria compared with control dogs. These findings suggest that, at least in part, high serum phosphate concentrations are related to the renal retention of phosphate.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26626505/